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FIGURE 4 Hence, it is the prevailing recommendation among endocrinologists that non-pregnant individuals with PCOS exhibiting abnormal glucose regulation, irrespective of their body weight status, initiate metformin therapy promptly upon diagnosis, with a prescribed duration of treatment lasting at least 3–6 months

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An amino acid substitution in the pyruvate dehydrogenase E1 alpha gene, affecting mitochondrial import of the precursor protein