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The focus of current research on the role of NAC in bone metabolism regulation via innate immunity primarily centers on macrophage modulation, with fewer studies addressing its effects on neutrophils, mast cells and other innate immune cells (Figure 1C)
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Furthermore, acyl-ghrelin was found to bind to the ghrelin receptor by effectively utilizing this “bifurcated pocket.” In addition to promoting GH secretion (Kojima et al., 1999), the ghrelin-ghrelin receptor system participates in appetite stimulation, body temperature regulation, and cardioprotection (Nakazato et al., 2001
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