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Conclusion E2F5 is an injurious factor in the pathogenesis of DAS, and the downregulation of E2F5 could repress VSMCs phenotype switching through inactivating Wnt/Ξ²-catenin pathway, and ultimately inhibit the progression of DAS
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This type of processing does not appear to be exclusive to GHRHR [29], although its physiological significance is unknown
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