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(2014, Nature) established NNMT as a major regulator of metabolic rate in white adipose tissue, showing that NNMT knockdown in mice produced a lean phenotype with elevated energy expenditure – providing the foundational rationale for NNMT inhibition as a metabolic research target
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tabacum cell suspension to elevated temperature (55°C) also resulted in increased GR activity (Locatto et al., 2009)
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