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Significant positive correlations were identified between oprd1 relative quantity and social investigation time (r 2 = 0.29, p = 0.015) and social preference (r 2 = 0.271, p = 0.019) in phase 1 of the 3CST

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These cytokines may cross the BBB, thereby inducing neuroinflammation across the reward pathway and altering synaptic plasticity, dendritic spine formation and myelination (34)