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Many effects of both pesticides and microbiome converge in impairing intestinal barrier integrity, leading to gut and systemic inflammation, with microbial metabolites playing an important role in mediating multiple inflammatory and metabolic cascades, finally resulting in an accumulation of misfolded α-syn and neurodegeneration
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This suggests that BDNF may reflect disease activity, and its fluctuation may be attributable to differences in population-level disease status (160)
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