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GCH1-mediated defense mechanism GTP cyclohydrolase-1 (GCH1) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin (BH4), a critical cofactor necessary for various biochemical processes, including the synthesis of monoamine neurotransmitters and the regulation of nitric oxide levels (178,179)
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By targeting IL-1β, interleukin-18 (IL-18), and type I interferon pathways, probiotics can fine-tune inflammasome activity, thereby suppressing aberrant inflammatory responses while simultaneously strengthening host antiviral defenses (236)
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