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Thalidomide, as a drug capable of inhibiting TNF-α protein synthesis, effectively slows down the progression of many cancers, including multiple myeloma, by blocking the synthesis of several growth factors, including VEGF, basic fibroblast growth factor, and hepatocyte growth factor, as well as inhibiting the synthesis of tumor deoxyribonucleic acid (DNA) (258, 259)

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Instead, the electrons ping back out and wind up getting donated to O2 to form massive quantities of superoxide