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Glutathione peroxidases (GPXs), an enzyme family with peroxidase activity, can protect organisms against oxidative damage by reducing lipid hydroperoxides and hydrogen peroxide ( Although mounting evidence suggests that GPX4 significantly contributes to the development of certain cancers, its exact role in cancer biology remains to be fully elucidated, and a comprehensive pan-cancer analysis which leverages multi-omics integration, has not yet been performed
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