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To view a copy of this license, visit About this article Cite this article Kim, M.J., Do, M., Han, D
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Among these, it worth mentioning that spliceosome downregulation corelated with upregulated chaperones, proteasomes, and ribosomes in liver and muscle cells, resulting in slightly impaired and energy-inefficient protein synthesis machinery, increased production of ketone bodies through Hmgcs2, downregulation of some mitochondrial OXPHOS components and the TCA cycle in the brain, and overexpression of proteins involved in the metabolism of xenobiotics in the liver
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