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Our mechanistic investigations revealed that intracellular GSSG elevation sensitizes hepatocytes to TNFα killing by inducing IKK-β-SSG formation, leading to suppressed NF-κB activation
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In contrast, the inhibition of complex I at the I Q site by rotenone increases ROS generation and induces apoptosis of breast cancer cells through the activation of the c-Jun N-terminal kinase (JNK) and p38 pathways
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