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ATP Binding Cassette Subfamily D Member 4 (ABCD4) and the Lysosomal Cobalamin Transport Escort Protein (LMBD1) Free vitamin B 12 is released into the cytoplasm by an ATP (adenosine-5′- triphosphate) Binding Cassette Subfamily D Member protein (ABCD4, encoded by the gene of the same name), a 68.6 kDa exporter located on the lysosomal membrane [83]
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Without adequate B12, DNA synthesis falters, producing enlarged, dysfunctional red blood cells characteristic of megaloblastic anemia
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