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Kir4.1 channels are functionally coupled to the glutamate transporters and the water transporter aquaporin-4 [306,307,308,309]
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Specifically, the pioneering work by Jungermann demonstrated the spatial division of carbohydrate metabolism across the rat liver lobule, with gluconeogenic enzymes predominantly localized in periportal regions and glycolytic enzymes located in pericentral regions (Katz et al., 1977a,b)
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