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The irAEs due to pembrolizumab typically include diarrhea, hypothyroidism, rash, hyperthyroidism, fatigue, constipation, pruritus, fever, cough, and myalgia (Table 1) [13,14,43,44]
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Consequently, it is hypothesized that genetic factors regulate IFN-mediated ICD, and targeting these factors may hold therapeutic promise, particularly considering the elevated levels of interferon production in the tumor microenvironment
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