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Infusion of exo-MLT in zebrafish exposed to 17β-trenbolone, a substance that induces hyperactivation of the orexinergic system, significantly reduced the expression of the orexin/hypocretin receptor type 2 ( HCRTR-2 ) in the lateral hypothalamic nucleus and thus restored a normal sleep-wake cycle, suggesting a direct regulatory effect of MLT on orexinergic transmission [25]
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The researchers continued on to study the effects of DSIP under hypoxic conditions that alter the respiratory activity in the mitochondria
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