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In an interesting cross-sectional study published in 2024, Wang and coworkers compared plasma lactoferrin levels in patients affected by glaucoma with different degrees of severity and healthy controls, showing good diagnostic accuracy of this biomarker in distinguishing between healthy subjects and patients affected by glaucoma, and between early and advanced stages of the disease [171]

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Additionally, nuclear factor erythroid 2-related factor 2 (NRF2) is a defensive mechanism against oxidative stress that regulates several antioxidant enzymes, such as NAD(P)H quinone dehydrogenase 1 (NQO1), catalase (CAT), haemoxygenase-1 (HO-1), and γ-glutamyl cysteine synthetase (GCS) [40,41,42,43]