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At any rate, the long-term role of NCC either as an ion transporter sensitive to thiazides, as an IL-18 receptor or as a potential partner for GLP-1 receptors in β-cells or in any capacity in metabolically active tissue awaits exploration, particularly within the context of obesity, the most prevalent component of MetS
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The defining idea behind the series is tissue specificity: each compound is modeled on extracts from a particular organ, and research has focused on whether it can selectively influence gene expression and protein synthesis in that same tissue
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