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Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider
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In contrast, the colon/large intestine, characterized by anaerobiosis, a slower passage of food, water for absorption, and undigested food for fermentation, is densely colonized with microbiota [20]
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