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In colorectal cancer, breast cancer and hepatocellular cancer, the activation of the Wnt/β-catenin pathway leads to a worse overall survival as high levels of CTNNB1 promotes metastasis and epithelial-mesenchymal transition (EMT) ( In contrast to a study by Wu et al., we did not find any correlation between the expression levels of GR and the immune cell infiltration levels or overall survival of the ACC patients ( In our study, we employed IHC to analyse LEF-1 expression, similar to the approach used in their West China Hospital (WCH) cohort