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Zanoni P, Velagapudi S, Yalcinkaya M, Rohrer L, von Eckardstein A
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The streptozotocin (STZ)‐induced rodent model of T1DM exhibits increased skeletal muscle neutral lipid staining (specifically DAG), Ceramide Synthase 1 (involved in ceramide synthesis) protein content, long‐chain fatty acid‐acyl‐coenzyme A esters (precursors to DAG and ceramide), and several lipid metabolites such as octadecenoic acid, linoleic acid, arachidonic acid, docosahexaenoic acid, and palmitic acid, despite well to moderately controlled glycemia with insulin treatment (Dotzert et al., 2016
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