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Recommendation : Vitamin B-12 (as cyanocobalamin) 2,500mcg or more, can be combined with Folic Acid 400 to 800 mcg, dissolved slowly under the tongue, the morning or early afternoon, once daily, or as directed by your healthcare provider

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Adding retatrutide 5 to 10 BPM on top of that pushes the total increase into a range where healthy individuals might notice uncomfortable cardiovascular symptoms